Cetylpyridinium Chloride (CPC)
Popkin et al. 20176
In vitro and in vivo study on Influenza virus (virus with lipid envelope like coronavirus)
Mechanism of action: CPC alters the lipid membrane of viruses with a lipid envelope through phisicochemical interactions, causing their rupture, and therefore, inactivation of the virus.
Transmission electron microscopy (TEM) demonstrating CPC disrupts the integrity of the viral envelope and morphology of influenza virus
CPC effectively inactivates viruses with a lipid envelope6.
Group A: Control (Untreated influenza virus)
Group B and C: Influenza virus treated with 0,0050% CPC for 5 minutes.
Viral particles exposed to CPC demonstrate disrupted envelope or cavitation (arrows)of viral units.
The presence of negative stain inside the virions indicates membrane permeabilization.
The scale bar is in the lower left corner at 100 nm (A) or 50 nm (B, C).
We quantified the number of intact and disrupted viruses after treatment:
Group A: 4,5% of viruses were disrupted
Group B and C: 86% of the viruses were disrupted A B C
Mukherjee et al. 20177
Clinical trial conducted with 94 healthy volunteers and its aim was to determine if the use of CPC applied orally
could prevent infections in the upper respiratory tract caused by influenza virus, respiratory syncytial virus, human
metapneumovirus, rhinovirus and adenovirus.
El CPC effectively prevents infections in the upper respiratory tract caused by viruses with a lipid envelope.